Tag: 1000 Exercicis Per Al Nivell C

1000 Exercicis Per Al Nivell C

1000 Exercicis Per Al Nivell C

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1000 Exercicis Per Al Nivell C

Hits: 2260Intra-hepatic artery infusion of 5-fluorouracil and systemic administration of leucovorin in patients with advanced gastrointestinal cancer: a phase II study.
Twenty-five patients with measurable advanced gastrointestinal cancer were treated with intra-hepatic artery infusion of 5-fluorouracil (1000 mg/m2, days 1 and 22) plus systemic administration of leucovorin (400 mg/m2, days 1 and 22). In addition to clinical observation, tumor response, toxicity and pharmacokinetic studies of 5-fluorouracil and its metabolites were performed. Of the 22 evaluable patients, seven (32%) had a partial response and 11 (50%) had stable disease lasting 4 to 12 months. Survival time was longer in the responders than in the non-responders. Objective tumor response was seen in the liver, lymph node, peritoneum, brain, lung, bone, and kidneys. Hematologic toxicity, mucosal toxicity and neurotoxicity were generally mild. The favorable response rate and survival time suggest that intra-hepatic artery infusion of 5-fluorouracil (1000 mg/m2) plus systemic administration of leucovorin (400 mg/m2) is a safe and active treatment for advanced gastrointestinal cancer, and that the regimen seems to be especially promising for patients with liver metastasis.WHAT’S ON:

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